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. 2020 Aug 26;10(9):1241. doi: 10.3390/biom10091241

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The total expression of proteins involved in the sphingolipid metabolism, e.g., (A) serine palmitoyltransferase, long chain base subunit 1 (SPTLC1), (B) ceramide synthase 5 (LASS5), (C) acid ceramidase (ASAH1), and (D) sphingosine kinase 2 (SPHK2), in the red gastrocnemius muscle in the control (standard diet) and high-fat diet (HFD) groups after chronic cannabidiol (CBD) treatment. The total expressions of the above proteins are presented as a percentage difference compared to the control group, which was set as 100%. The data are expressed as mean values ± SD, n = 6 in each group. ^a p < 0.05 significant difference: control group vs. examined group; ^b p < 0.05 significant difference: HFD vs. HFD + CBD.