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. 2020 Aug 26;10(9):1241. doi: 10.3390/biom10091241

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Effects of a high-fat diet (HFD) and chronic cannabidiol (CBD) administration on the sphingolipid metabolic pathway in rat myocytes. ↑, increase; ↓, decrease; red arrows indicate the effects of high-fat feeding; green arrows indicate the effects of CBD treatment; serine palmitoyltransferase, long chain base subunit 1 (SPTLC1); ceramide synthase 5 (LASS5); dihydroceramide desaturase (DES); neutral sphingomyelinase (NSmase); UDP-glucose ceramide glucosyltransferase (UGCG); ceramide synthase (CerS); acid ceramidase (ASAH1); sphingosine kinase 2 (SPHK2); phosphorylated protein kinase B (pAkt); phosphorylated glycogen synthase kinase 3 (pGSK-3).