Architecture and analysis of BCEH of envelope E protein. (a) a graphical depiction of E protein with Pfam domains, architecture, disorder and BCEH localization. Color blocks: Pfam domains (grey), alpha-helices (orange), transmembrane helices (yellow), disordered regions (black), and BCEH (white); (b) phylogenetic tree of 32 non-redundant coronavirus E sequences calculated by the Neighbor-Joining method. No bootstrap value reached a value of 100; (c) SARS-CoV-2 BCEH-E sequence and changes observed in relation to SARS-CoV E protein: capital letters indicate epitopes, residues conserved ≥90% sequences (dots), changed to unique option (≥90%, red), deletions (dashes).