Table 1.
Characteristics of melanoma patients at leptomeningeal disease diagnosis.
| Characteristics | Number of Patients (%) | |
|---|---|---|
| Median Age: 55 Years (Range: 50–67) | ||
| Sex | Female | 11 (38%) |
| Male | 18 (62%) | |
| ECOG | 0 | 12 (42%) |
| 1 | 10 (34%) | |
| 2 | 4 (14%) | |
| 3 | 2 (7%) | |
| 4 | 1 (3%) | |
| Serum LDH | Normal | 20 (69%) |
| Elevated | 9 (31%) | |
| BRAF | Wild type | 15 (52%) |
| Mutated | 13 (45%) | |
| NA | 1 (3%) | |
| NRAS | Wildtype | 15 (52%) |
| Mutated | 11 (38%) | |
| NA | 3 (10%) | |
| Primary melanoma site | Trunk | 6 (22%) |
| Arms | 7 (24%) | |
| Leg | 3 (10%) | |
| Acral lentiginous | 5 (17%) | |
| Head | 1 (3%) | |
| NA | 7 (24%) | |
| MBM at LM diagnosis | Yes | 19 (66%) |
| No | 10 (34%) | |
| Number of MBM at LM diagnosis | 1 | 5 (18%) |
| 2–4 | 10 (35%) | |
| 5–9 | 3 (10%) | |
| >10 | 1 (3%) | |
| Size of MBM | <2 cm | 13 (45%) |
| >2 cm | 6 (21%) | |
| Corticosteroids | Yes | 7 (24%) |
| <0.5 mg/kg/day | 4 (14%) | |
| >0.5 mg/kg/day | 3 (10%) | |
| Previous radiotherapy for MBM | No | 12 (42%) |
| SRS | 10 (34%) | |
| WBRT | 4 (14%) | |
| SRS and WBRT | 3 (10%) | |
| Previous surgical resection of brain metastases | Yes | 5(17%) |
| No | 24 (83%) | |
| Number of previous systemic line | 0 | 14 (48%) |
| 1 | 6 (21%) | |
| 2 | 5 (17%) | |
| 3 | 2 (7%) | |
| 4 | 2 (7%) | |
| Neurological symptoms | Yes | 15 (52%) |
| No | 14 (48%) | |
| CSF cytology | Negative | 1 (3%) |
| Positive | 1 (3%) | |
| NA | 27 (94%) | |
| Radiographic findings of LM | Yes | 29 (100%) |
| No | 0 (0%) | |
CSF: cerebrospinal fluid; ECOG: Eastern Cooperative Oncology Group; NA: data unavailable; LM: leptomeningeal metastases; MBM: melanoma brain metastases; SRS: stereotactic radiosurgery; WBRT: whole brain radiation therapy.