Table 2.
Univariate and multivariate analysis: factors associated with overall survival after diagnosis of leptomeningeal disease.
| Analyzed Factors | Univariate Analysis | Multivariate Analysis *** | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Treatment ** | 1.45 (0.64–3.29) | 0.37 | NR | NR |
| Sex * | 0.86 (0.37–1.97) | 0.72 | NR | NR |
| Age * | 0.99 (0.96–1.02) | 0.54 | NR | NR |
| LDH * | 1.44 (1.09–1.90) | <0.01 | 1.52 (1.14–1.95) | <0.01 |
| ECOG * | 1.46 (0.64–3.35) | 0.37 | NR | NR |
| BRAF * | 0.53 (0.23–1.21) | 0.13 | 0.45 (0.17–1.19) | 0.23 |
| MBM * | 0.63 (0.27–1.51) | 0.30 | NR | NR |
| Neurological symptoms * | 2.96 (1.25–6.99) | 0.01 | 2.35 (0.9–6.1) | 0.08 |
HR: hazard ratio; LDH: lactate dehydrogenase level; ECOG: Eastern Cooperative Oncology Group; MBM: melanoma brain metastases. * at LM diagnosis. ** systemic treatment (immunotherapy, targeted therapy, chemotherapy) received after LM diagnosis. *** Only variables with p value inferior or equal to 0.20 in univariate analysis were included in multivariate analysis.