Table 2.
Validation of the GEO DataSets selected miRNAs in the Cancer Genome Atlas Breast Cancer database.
| miRNA | GEO Datasets log2FC Average | TCGA BRCA | |
|---|---|---|---|
| p-Value | |||
| Upregulated miRNAs | |||
| hsa-miR-103a-3p | 1.044 | 1.532 | 1.031 × 10−19 |
| hsa-miR-106b-5p | 1.000 | 2.423 | 7.270 × 10−28 |
| hsa-miR-107 | 0.882 | 1.676 | 3.424 × 10−17 |
| hsa-miR-141-3p | 1.476 | 5.343 | 2.723 × 10−29 |
| hsa-miR-142-3p | 1.775 | 3.040 | 2.214 × 10−18 |
| hsa-miR-142-5p | 1.413 | 2.283 | 1.313 × 10−13 |
| hsa-miR-146a-5p * | 0.902 | #N/D | #N/D |
| hsa-miR-155-5p | 1.443 | 1.961 | 4.674 × 10−18 |
| hsa-miR-15b-5p | 1.076 | 1.908 | 1.745 × 10−11 |
| hsa-miR-16-5p | 0.955 | 1.591 | 2.960 × 10−8 |
| hsa-miR-181b-5p | 0.616 | 2.219 | 1.238 × 10−22 |
| hsa-miR-182-5p | 2.027 | 4.799 | 2.421 × 10−40 |
| hsa-miR-183-5p | 2.759 | 7.102 | 3.388 × 10−47 |
| hsa-miR-185-5p | 0.883 | 1.548 | 2.932 × 10−9 |
| hsa-miR-18a-5p | 1.714 | 1.905 | 5.766 × 10−14 |
| hsa-miR-200a-3p | 1.346 | 3.948 | 2.352 × 10−26 |
| hsa-miR-200b-3p | 1.564 | 2.846 | 4.468 × 10−20 |
| hsa-miR-200c-3p | 1.298 | 2.691 | 2.049 × 10−17 |
| hsa-miR-203a-3p | 1.055 | 2.287 | 2.680 × 10−14 |
| hsa-miR-21-5p | 2.054 | 4.448 | 5.680 × 10−41 |
| hsa-miR-210-3p | 1.244 | 5.632 | 1.111 × 10−31 |
| hsa-miR-25-3p * | 0.946 | #N/D | #N/D |
| hsa-miR-301a-3p | 1.620 | 2.314 | 7.058 × 10−24 |
| hsa-miR-340-5p | 0.924 | 2.001 | 8.384 × 10−25 |
| hsa-miR-425-5p | 1.733 | 1.740 | 8.393 × 10−8 |
| hsa-miR-429 | 1.751 | 4.884 | 6.208 × 10−33 |
| hsa-miR-484 | 0.792 | 1.399 | 2.801 × 10−6 |
| hsa-miR-7-5p | 1.786 | 1.850 | 7.483 × 10−21 |
| hsa-miR-93-5p | 1.209 | 2.110 | 5.223 × 10−26 |
| hsa-miR-96-5p | 2.178 | 6.970 | 7.515 × 10−47 |
| Downregulated miRNAs | |||
| hsa-miR-100-5p | −1.574 | −4.066 | 1.191 × 10−52 |
| hsa-miR-1229-3p | −0.819 | 1.274 | 2.105 × 10−6 |
| hsa-miR-125b-5p | −1.819 | −4.107 | 6.680 × 10−48 |
| hsa-miR-130a-3p | −0.996 | −2.371 | 2.085 × 10−30 |
| hsa-miR-139-3p | −1.178 | −8.512 | 2.131 × 10−52 |
| hsa-miR-139-5p | −2.444 | −8.699 | 6.482 × 10−58 |
| hsa-miR-143-3p | −1.422 | −2.288 | 1.458 × 10−28 |
| hsa-miR-145-3p | −1.501 | −3.196 | 7.255 × 10−54 |
| hsa-miR-145-5p | −2.015 | −5.892 | 2.501 × 10−50 |
| hsa-miR-195-5p | −1.541 | −2.867 | 1.560 × 10−39 |
| hsa-miR-202-3p * | −1.198 | #N/D | #N/D |
| hsa-miR-205-5p | −2.033 | −5.921 | 4.198 × 10−35 |
| hsa-miR-335-5p | −1.961 | −4.846 | 4.980 × 10−27 |
| hsa-miR-376a-3p | −1.441 | −1.364 | 2.287 × 10−8 |
| hsa-miR-377-3p | −1.542 | −1.418 | 2.186 × 10−7 |
| hsa-miR-381-3p | −1.523 | −2.486 | 3.350 × 10−26 |
| hsa-miR-486-5p | −1.496 | −10.611 | 3.737 × 10−26 |
| hsa-miR-497-5p | −1.254 | −2.726 | 1.543 × 10−33 |
| hsa-miR-99a-5p | −1.433 | −5.165 | 6.270 × 10−63 |
* Non-significantly dysregulated miRNAs in the TCGA BRCA database; in bold miRNAs with discordant expression levels between the GEO DataSets and TCGA databases.