Table 3.

Molecular and signaling transduction pathways altered by the 10 miRNAs modulated by exercise and involved in cancer.

KEGG Pathway	p-Value	N. of Targeted Genes	Involved miRNAs
Pathways in cancer (hsa05200)	4.05564 × 10−7	179	10
PI3K-Akt signaling pathway (hsa04151)	0.011123026	140	10
Proteoglycans in cancer (hsa05205)	2.21725 × 10−17	107	10
MAPK signaling pathway (hsa04010)	0.011123026	104	10
Viral carcinogenesis (hsa05203)	6.08511 × 10−8	95	10
Transcriptional misregulation in cancer (hsa05202)	0.002760238	80	10
Hippo signaling pathway (hsa04390)	1.31008 × 10−8	76	10
FoxO signaling pathway (hsa04068)	1.48491 × 10−6	71	10
Cell cycle (hsa04110)	3.14391 × 10−5	66	10
Insulin signaling pathway (hsa04910)	0.009388457	65	10
AMPK signaling pathway (hsa04152)	0.006097228	62	10
Thyroid hormone signaling pathway (hsa04919)	0.000182888	61	10
HIF-1 signaling pathway (hsa04066)	3.77879 × 10−5	57	10
TNF signaling pathway (hsa04668)	0.014299582	54	10
Prostate cancer (hsa05215)	2.74229 × 10−5	52	10
Small cell lung cancer (hsa05222)	2.1672 × 10−5	50	10
Estrogen signaling pathway (hsa04915)	0.00014031	47	10
ErbB signaling pathway (hsa04012)	0.001313884	45	9
Chronic myeloid leukemia (hsa05220)	1.45098 × 10−6	44	10
Renal cell carcinoma (hsa05211)	1.69642 × 10−7	42	10
TGF-beta signaling pathway (hsa04350)	4.62474 × 10−6	41	10
Pancreatic cancer (hsa05212)	9.61555 × 10−6	40	10
Colorectal cancer (hsa05210)	5.0244 × 10−7	39	10
p53 signaling pathway (hsa04115)	0.00014031	39	10
Apoptosis (hsa04210)	0.018765462	38	10
Glioma (hsa05214)	2.56338 × 10−6	37	10
Central carbon metabolism in cancer (hsa05230)	2.56338 × 10−6	36	10
Non-small cell lung cancer (hsa05223)	8.72499 × 10−6	34	10
ECM-receptor interaction (hsa04512)	1.96805 × 10−5	34	10
mTOR signaling pathway (hsa04150)	0.003253273	34	10
Melanoma (hsa05218)	0.009412459	34	10
Endometrial cancer (hsa05213)	3.18028 × 10−5	32	10
Acute myeloid leukemia (hsa05221)	0.019544711	29	10
Bladder cancer (hsa05219)	0.000423154	25	9
Thyroid cancer (hsa05216)	0.000804104	17	10