Table 3.
Analysis of risk factors for hereditary and familial gastric and pancreatic cancer. Univariate and multivariate analysis of factors associated with the detection of: a high-risk form (a); or hereditary syndrome (b).
| (a) Factors Associated with High Risk Condition of Cancer (Hereditary or Familial Cancer) | ||||
| Characteristic | Sporadic Cancer (48) | High Risk Form (29) | p-Value (Univariate) |
OR (95% CI); p-Value
(Multivariate) |
| Age, years; median (IQR) | 53 (41.5–67) | 49 (41.2–55.5) | 0.084 | 0.98 (0.92–1.03); p = 0.46 |
| Gender: women; number (%) | 29 (60.4) | 17 (58.6) | 0.876 | - |
| PH of other cancer | 4 (8.3) | 5 (17.2) | 0.252 | - |
| Referral criteria: | ||||
| Age ≤ 60 years old | 42 (87.5) | 9 (31) | 0.000 | 0.16 (0.008–3.37); p = 0.24 |
| Multiplicity | 2 (4.1) | 1 (3.4) | 0.875 | - |
| Family history | 4 (8.3) | 19 (65.5) | 0.000 | 21 (5.8-79); p = 0.000 |
| (b) Factors Associated with Hereditary Cancer (Only Cases with Pathogenic Mutation Identified) | ||||
| Characteristic | Non-Hereditary Cancer (67) | Hereditary Syndrome (10) | P-Value (univariate) | OR (95% CI); p-Value (multivariate) |
| Age, years; median (IQR) | 50 (43–59) | 39.5 (33.7–50.5) | 0.041 | |
| Younger case age < 40 | 10 (15) | 5 (50) | 0.009 | 11.3 (1.9–67); 0.007 |
| Gender: women; number (%) | 41 (61.2) | 5 (50) | 0.501 | |
| PH of other cancer | 5 (7.4) | 4 (40) | 0.003 | 17.4 (2.5–119.9); p = 0.004 |
| Referral criteria: | ||||
| Age ≤ 60 years old | 45 (67.2) | 6 (60) | 0.655 | |
| Multiplicity | 2 (2.9) | 1 (10) | 0.285 | |
| Family history | 20 (29.8) | 3 (30) | 0.992 | |
IQR, interquartile range; OR, odds ratio; CI, confidence interval; PH, personal history.