Table 3.
Univariate and multivariate analysis of baseline variables on PFS and OS.
| Variable | HR | 95% CI | p | |
|---|---|---|---|---|
| PFS | ||||
| Univariate Analysis | ||||
| Age | 1.562 | 1.031 | 2.365 | 0.035 |
| Sex | 1.478 | 1.017 | 2.148 | 0.040 |
| R-ISS 1 vs 2-3 | 1.217 | 0.813 | 1.847 | 0.354 |
| R-ISS 1-2 vs 3 | 1.504 | 0.873 | 2.589 | 0.141 |
| Autograft Arm | 0.683 | 0.475 | 0.982 | 0.039 |
| FL DS 1-2-3 vs 4-5 | 1.098 | 0.756 | 1.594 | 0.622 |
| BM DS 1-2-3 vs 4-5 | 1.180 | 0.816 | 1.706 | 0.380 |
| FLs Number < 1* | 0.868 | 0.503 | 1.172 | 0.221 |
| Presence of EMD | 2.324 | 1.246 | 4.335 | 0.008 |
| FLs SUVmax ≤ 2.9* | 0.634 | 0.424 | 0.946 | 0.026 |
| Bone SUVmax ≤ 3.4* | 0.528 | 0.307 | 0.907 | 0.021 |
| BM SUVmax ≤ 3.3* | 0.720 | 0.499 | 1.041 | 0.081 |
| Multivariate Analysis | ||||
| Presence of EMD | 2.510 | 1.297 | 4.869 | 0.006 |
| Autograft Arm | 0.640 | 0.442 | 0.938 | 0.022 |
| OS | ||||
| Univariate Analysis | ||||
| Age | 0.591 | 0.322 | 1.089 | 0.091 |
| Sex | 1.108 | 0.621 | 1.978 | 0.728 |
| R-ISS 1 vs 2-3 | 1.313 | 0.669 | 2.575 | 0.428 |
| R-ISS 1-2 vs 3 | 1.836 | 0.857 | 3.930 | 0.118 |
| Autograft Arm | 1.051 | 0.727 | 1.518 | 0.792 |
| FL DS 1-2-3 vs 4-5 | 1.139 | 0.630 | 2.0.58 | 0.666 |
| BM DS 1-2-3 vs 4-5 | 1.457 | 0.823 | 2.577 | 0.196 |
| FLs Number < 1* | 0.521 | 0.244 | 1.115 | 0.093 |
| Presence of EMD | 2.107 | 0.894 | 4.965 | 0.088 |
| FLs SUVmax ≤ 6.3* | 0.501 | 0.283 | 0.887 | 0.018 |
| Bone SUVmax ≤ 7.1* | 0.462 | 0.262 | 0.814 | 0.007 |
| BM SUVmax ≤ 5.9* | 0.450 | 0.241 | 0.840 | 0.012 |
| Multivariate Analysis | ||||
| Bone SUVmax > 7.1* | 2.020 | 1.140 | 3.592 | 0.016 |
R-ISS: revised International Staging System; EMD: extra-medullary disease; FLs: focal lesions; BM: bone marrow; SUV: standard uptake value; DS: Deauville score; *optimum threshold defined by Maximally selected Rank Statistics method.