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Treatment of xenograft tandem-cultures based on (A,B) U-87 MG or (C,D) G55T2 cell xenografts with the Pim1 inhibitor SGI-1776 vs. solvent control. (A,C) representative microscopic pictures of Vimentin staining (asterisk: necrotic area). (B,D) Results of the quantitation of the tumor invasion index or space occupying tumor growth. Scale bars: 200 µm; * = p < 0.05.
