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. 2020 Sep 15;9(9):2980. doi: 10.3390/jcm9092980

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Frozen-thawed ovarian tissue from 7 adult patients was distributed equally among the following groups: non-grafted controls, OT group (one-step transplantation to 7 SCID mice), and 2-step/ASCs+OT group (two-step transplantation to 7 SCID mice). The first step (ASCs loaded inside fibrin scaffolds) was carried out 2 weeks before the second step (OTT). Blood was taken every 4 weeks until euthanasia (after 24 weeks) and sample retrieval for histology and immunolabeling. (B) Human ovarian tissue retrieval from SCID mouse peritoneum after 6 months of transplantation in the 2-step/ASCs+OT group. Grafted ovarian tissue (1) with an antral follicle (2) and macroscopically visible vasculature (3) derived from mouse peritoneum (4). SCID: severe combined immunodeficient. ASCs: adipose tissue-derived stem cells. OT: ovarian tissue. OTT: ovarian tissue transplantation.