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. 2020 Aug 25;12(9):2410. doi: 10.3390/cancers12092410

Figure 4.

Figure 4

miRNA content in plasma samples. Plasma miRNAs levels (copies/µL) in Tumor-free Donors (from Tf-D1 to Tf-D8) and CRC (from CRC1 to CRC46) plasma samples. Values detected by dd-RT-PCR. The dotted green and red boxes in the control samples indicate the plasma lowest (green) and highest (red) miRNA levels used for comparison with the CRC samples. In the CRC samples, the solid green boxes show down-regulated miRNA values (lower values with respect to the lowest values found in controls), while the solid red boxes show up-regulated miRNA values (higher values with respect to the highest values found in controls). The number of dysregulated miRNAs is indicated from each CRC sample in the last right columns (this numbers in several CRC samples increase considering the analysis of miR-141-3p, miR-221-3p and miR-222-3p shown in Figure 1C). A further analysis comparing CRC values with the average values found in controls is reported in Figure S2. A comparison of miR-15b-5p, miR-584-5p and miR-425-3p (displaying an upregulation trend in CRC samples), and miR-141-3p, miR-221-3p and miR-222-3p, is shown in Table S3.