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. 2020 Aug 25;12(9):2410. doi: 10.3390/cancers12092410

Figure 5.

Figure 5

Digital droplet RT-PCR validation and principal component analysis (PCA). (A): Digital droplet RT-PCR validation (dd-RT-PCR) comparing plasma samples from 35 CRC patients and 6 tumor-free donors with respect to the content of dysregulated miRNAs. (B): PCA captured the variation observed in the experiment in the first three principal components (PC). Three principal microRNA sets on the basis of their respective correlations can be proposed, as depicted in the panel. The nine miRNAs of the proposed signature, plus the miR-141-3p, miR-221-3p and miR-222-3p, were considered.