Table 3.

Overview of differentially abundant lipids by day. A two-sided permutation paired t-test was used to determine lipids with post-vaccination plasma molar concentrations that significantly differed compared to pre-vaccination. Lipids with a p-value < 0.05 and an increase/decrease from pre-vaccination of at least 20% (±1.2-fold) were deemed differentially abundant.

Lipid Name	Lipid ID	Lipid Class	Day	Fold Change	t-Statistic	p-Value
16:1 LPC	TULIPID017	PC	Day 1	0.709	−2.7	0.0137
20:3 LPC	TULIPID024	PC	Day 1	0.74	−5.5	0.002
36:3 PE	TULIPID103	PE	Day 1	1.238	1.8	0.0469
p40:6 PE	TULIPID119	PE	Day 1	1.214	2.4	0.0449
16:1 CE	TULIPID078	CE	Day 2	0.811	−4.7	0.0039
16:1 LPC	TULIPID017	PC	Day 2	0.597	−2.9	0.0234
20:3 LPC	TULIPID024	PC	Day 2	0.62	−3.8	0.0078
22:3 CE	TULIPID089	CE	Day 2	0.376	−2.6	0.0371
34:1 PI	TULIPID058	PI	Day 2	0.388	−2.7	0.0254
34:2 PE	TULIPID099	PE	Day 2	0.797	−3.4	0.0098
AEA	TULIPID002	OXY	Day 2	0.686	−2.7	0.0312
OEA	TULIPID001	OXY	Day 2	0.682	−3.0	0.0156
16:1 CE	TULIPID078	CE	Day 7	0.824	−2.2	0.0371
16:1 LPC	TULIPID017	PC	Day 7	0.534	−2.6	0.0312
20:3 LPC	TULIPID024	PC	Day 7	0.598	−3.0	0.0195
22:0 Cer	TULIPID072	Cer	Day 7	0.807	−2.9	0.0254
38:3 PI	TULIPID064	PI	Day 7	0.491	−2.4	0.0469
5-HETE	TULIPID012	OXY	Day 7	0.386	−2.7	0.0312
Summed DHET Species	TULIPID007	OXY	Day 7	1.969	3.1	0.0215
5-HETE	TULIPID012	OXY	Day 14	0.674	−2.3	0.0488