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. 2020 Sep 2;12(9):2489. doi: 10.3390/cancers12092489

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Signalling pathways regulated by protein–coding genes (PCGs) according to Gene Ontology (GO), Reactome and Kyoto Encyclopedia of Genes and Genomes (KEGG) database. (A) Top statistically significant enriched signalling pathways (−log10p > 6) with accumulative hypergeometric p–values and enrichment factors calculated and used for filtering from overall enrichment analysis. (B) Enriched ontology clusters shown as a network only for the subset of representative biological processes (−log10p > 6, accumulative hypergeometric p–values) from the full enrichment analysis. Each term is represented by a circle node. Top statistically significant terms are hierarchically clustered into a tree based on Kappa–statistical similarities (score > 0.3) among their gene memberships, linked by an edge (the thickness of the edge represents the similarity score). Each cluster has a colour and term description.