Table 2.

Summary of influences of host, viral load, and CD4+ T cell counts on viral load rebound.

CD4+ T Cell Count and PreART Viral Load
Chronic HIV-1 Infected Patients
A lower nadir CD4+ T cell count and higher preART viral load had a shorter time to ART resumption	Autran [33]
CD4+ T cell count and higher preART viral load correlated with time to ART resumption	Huang [34]
preART viral load correlated with shorter time to viral load rebound	Li [35]
Patients Treated During Acute HIV-1 Infection
No evidence of effect of CD4+ T cell count or preART VL	Colby [36]
HLA
The number of HLA-associated polymorphisms in Gag predicted peak of viremia after ATI. No influence of the presence of protective HLA class I alleles (B*57, B*27 or B*51) or number of HLA footprints in Gag were associated with time to rebound of viral load	Rosas-Umbert [37]
Participants with neutral HLA alleles had lower median VL 16 weeks after ATI than did vaccinated participants with protective HLA alleles or placebo participants with neutral HLA alleles. Factors independently associated with lower VL 16 weeks after ATI included greater Gag sequence divergence from the vaccine sequence and decreased proportion of HLA-associated polymorphisms in Gag	Li [35]

Note: ART: antiretroviral therapy; VL: viral load; ATI: analytical treatment interruption; HLA: human leukocyte antigen.