Table 2.
Most potent SARS-CoV-2–derived MHC class I binding epitopes identified with both the IEDB (lowest IC50) and NetCTL1.2 (highest combined score) in silico prediction methods.
| Epitopes | Protein | Allotype | Supertype | Combined Score | Predicted IC50 (nM) |
|---|---|---|---|---|---|
| 738DTDFVNEFY746 | RdRp | A*01:01 | A01 | 3.619 | 2.83 |
| 1505LVAEWFLAY1513 | nsp3 | A*29:02 | A01 | 2.748 | 3.02 |
| 289SHFAIGLAL297 | Helicase | B*39:01 | B39 | 2.168 | 4.55 |
| 1507AEWFLAYIL1515 | nsp3 | B*40:01 | B44 | 2.036 | 4.88 |
| 1505LVAEWFLAY1513 | nsp3 | B*35:01 | A01 | 2.748 | 5.66 |
| 1507AEWFLAYIL1515 | nsp3 | B*40:02 | B44 | 2.036 | 7.64 |
| 217AMDEFIERY225 | EndoR | A*01:01 | A01 | 3.138 | 10.47 |
| 1505LVAEWFLAY1513 | nsp3 | B*15:01 | A01 | 2.748 | 11.16 |
| 1505LVAEWFLAY1513 | nsp3 | A*26:01 | A01 | 2.748 | 18.88 |