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. 2020 Sep 21;12(9):2697. doi: 10.3390/cancers12092697

Figure 4.

Figure 4

A common drug combination active in RCC cell lines. (A) Erlotinib and dasatinib, alone or combined with AZD4547 and/or axitinib were tested in the clear cell RCC lines that all selected for an ODC containing these compounds. Concentrations used per cell line were as used in the s-FSC. The same combinations were applied to activated endothelial cells (EC-RF24) and normal human dermal fibroblasts (HDFA). In the bottom panels, the monotherapies are displayed, which show only minimal inhibition. Experiments (N = 3–4) were performed in triplicate and mean ± SEM are presented. (B) Erlotinib and dasatinib, combined with AZD4547 and/or axitinib as 3- and 4-drug combinations tested in pRCC. Caki-2 and ACHN show notable sensitivity to these combinations while their original ODC selected (partially) different drugs. Experiments (N = 3–4) were performed in triplicate and mean ± SEM are presented. (C) Schematic of the major cellular pathways and TKI interactions for the common RCC drug combination.