Table 4.
Short-term and Long-term Predictors of Outcome following Inpatient Treatment.
| Variable | β (SE) | Odds Ratio (95% CIs) | P Value |
|---|---|---|---|
| Predictors of outcomes at discharge using logistic regression (responders 211 [50.2%]; nonresponders 209 [49.8%]) | |||
| Duration of illness (years) | −0.042 (0.015) | 0.959 (0.93to 0.988) | 0.006 |
| Sex (0 = male; 1 = female) | 0.624 (0.235) | 1.866 (1.178 to 2.956) | 0.008 |
| PC-1 (symmetry/arranging) | −0.003 (0.106) | 0.997 (0.81 to 1.227) | 0.977 |
| PC-2 (contamination/washing) | −0.253 (0.113) | 0.776 (0.623 to 0.968) | 0.025 |
| PC-3 (hoarding/collecting) | −0.062 (0.113) | 0.94 (0.753 to 1.174) | 0.587 |
| PC-4 (pathological doubts/checking) | 0.041 (0.107) | 1.041 (0.844 to 1.285) | 0.705 |
| PC-5 (forbidden thoughts) | 0.054 (0.11) | 1.055 (0.851 to 1.308) | 0.625 |
| YBOCS total score | −0.01 (0.024) | 0.99 (0.944 to 1.039) | 0.688 |
| Insight (0 = good, 1 = poor) | −1.13 (0.329) | 0.323 (0.17 to 0.615) | 0.001 |
| Number of failed adequate SRI trials | −0.129 (0.105) | 0.879 (0.716 to 1.08) | 0.219 |
| Past CBT failed (0 = no, 1 = yes) | −0.343 (0.254) | 0.709 (0.431 to 1.167) | 0.176 |
| Number of failed augmentation trials | −0.12 (0.126) | 0.887 (0.693 to 1.136) | 0.342 |
| Comorbid major depressive disorder (current) | 0.233 (0.221) | 0.792 (0.513 to 1.221) | 0.291 |
| Comorbid psychosis (lifetime) | −0.488 (0.438) | 1.63 (0.69 to 3.846) | 0.265 |
| Comorbid personality disorder | −0.394 (0.236) | 1.483 (0.933 to 2.356) | 0.095 |
| Constant | 0.769 (0.916) | — | 0.401 |
| Predictors of long-term outcome trajectory classes using conditional latent class growth analysis | |||
| Class 1: “Nonresponders” (14.6%): Reference class | |||
| Class 2: “Minimal responders” (34.7%) | |||
| Duration of illness (years) | −0.08 (0.039) | 0.923 (0.855 to 0.996) | 0.038 |
| Sex (0 = male, 1 = female) | 0.297 (0.571) | 1.346 (0.439 to 4.121) | 0.603 |
| PC-2 (contamination/washing) | −0.611 (0.385) | 0.543 (0.255 to 1.154) | 0.112 |
| Insight (0 = poor, 1 = good) | −0.368 (0.592) | 0.692 (0.217 to 2.209) | 0.534 |
| Class 3: “Remitters” (14.5%) | |||
| Duration of illness (years) | −0.341 (0.319) | 0.711 (0.381 to 1.329) | 0.285 |
| Sex (0 = male, 1 = female) | 0.558 (0.601) | 1.747 (0.538 to 5.674) | 0.353 |
| PC-2 (contamination/washing) | −0.979 (0.416) | 0.376 (0.166 to 0.849) | 0.018 |
| Insight (0 = poor, 1 = good) | 1.747 (1.161) | 5.737 (0.589 to 55.844) | 0.133 |
| Class 4: “Responders” (36.3%) | |||
| Duration of illness (years) | −0.133 (0.038) | 0.875 (0.813 to 0.943) | 0.001 |
| Sex (0 = male, 1 = female) | 0.024 (0.502) | 1.024 (0.383 to 2.74) | 0.962 |
| PC-2 (contamination/washing) | −0.897 (0.328) | 0.408 (0.214 to 0.776) | 0.006 |
| Insight (0 = poor, 1 = good) | 0.992 (0.622) | 2.697 (0.797 to 9.126) | 0.11 |
Note. N = 420. YBOCS = Yale Brown Obsessive-Compulsive Scale; CBT = cognitive behavioral therapy.