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. 2020 Jul 9;8(3):368. doi: 10.3390/vaccines8030368

Figure 2.

Figure 2

Figure 2

Liver lesions in YFV 17D-infected IFNAR-/- female mice. (a) Overt white necrotic lesions visible in the liver of an infected mouse day 6 post infection (white arrows). (b) A liver of an uninfected mouse with no white lesions. (c) H & E of necrotic liver lesion in YFV 17D-infected mouse. Paucity of blue nuclei evident in the necrotic lesion (pink), with inflammatory infiltrates (blue nuclei) at the periphery. (d) IHC of parallel section (from c) stained with the anti-flavivirus monoclonal antibody 4G4. Staining (brown) is clearly visible at the periphery of the necrotic lesion and in inflammatory foci (top left and right). Light counterstaining with haematoxylin (blue) show cell nuclei. (e) IHC staining with a control monoclonal antibody. (f) Councilman bodies (black dotted ovals) observed by H & E staining of livers from four YFV 17D-infected mice. (g) Top; steatosis (accumulation of lipid droplets in hepatocytes) visible as small white rounded inclusions in a liver of a YFV 17D-infected mouse. Bottom; uninfected control liver.