Table 1.
Histological features of mouse liver H & E stained sections day 6 post YFV 17D challenge (see Figure 3. Enumeration is per liver section. Distances (in µm) represent the maximum distance (edge to edge) for each lesion, or range of distances for the indicated number of lesions.
| Buffer | |
| Mouse 1 | Councilman bodies. 15 infiltrate foci (16–52 µm). Marked steatosis |
| Mouse 2 | Councilman bodies. 29 infiltrate foci (10–114 µm). Mild steatosis |
| Mouse 3 | Councilman bodies. 22 infiltrate foci (20–52 µm). Mild steatosis |
| Mouse 4 | 3 infiltrate foci (15–34 µm) |
| Mouse 5 | Necrotic lesion (325 µm). Councilman bodies. 17 infiltrate foci (17–104 µm). Mild steatosis |
| Mouse 6 | Necrotic lesions (212 and 43 µm). Councilman bodies. 18 infiltrate foci (15–52 µm). Mild steatosis |
| Buffer + adjuvant | |
| Mouse 1 | Councilman bodies. 6 infiltrate foci (18–27 µm). Small patches of steatosis. |
| Mouse 2 | Necrotic lesion (105 µm). Councilman bodies. 16 infiltrate foci (22–54 µm) |
| Mouse 3 | Councilman bodies. 16 infiltrate foci (21–63 µm) |
| Mouse 4 | Necrotic lesions (342 and 197 µm). Councilman bodies. 14 infiltrate foci (16–108 µm). Areas of marked steatosis |
| Mouse 5 | Councilman bodies. 22 infiltrate foci (17–109 µm). Small patches of steatosis |
| Mouse 6 | Necrotic lesions (357 and 123 µm). Councilman bodies. 30 infiltrate foci (21–79 µm) |
| 5 µg BinJ/YFV-prME + adjuvant | |
| Mouse 1 | 7 infiltrate foci (29–53 µm) |
| Mouse 2 | 6 infiltrate foci (15–38 µm) |
| Mouse 3 | 11 infiltrate foci (12–42 µm) |
| Mouse 4 | 11 infiltrate foci (13–77 µm) |
| Mouse 5 | 6 infiltrate foci (18–82 µm) |
| Mouse 6 | 7 infiltrate foci (18–34 µm) |
| 20 µg BinJ/YFV-prME + adjuvant | |
| Mouse 1 | 5 infiltrate foci (14–28 µm) |
| Mouse 2 | 5 infiltrate foci (21–50 µm) |
| Mouse 3 | 5 infiltrate foci (24–44 µm) |
| Mouse 4 | 5 infiltrate foci (19–35 µm) |
| Mouse 5 | 6 infiltrate foci (19–139 µm) |
| Mouse 6 | 3 infiltrate foci (26–43 µm) |
| Naïve mice (no vaccine, no challenge) | |
| Mouse 1 | 2 infiltrate foci (24–31 µm) |
| Mouse 2 | 3 infiltrate foci (31–69 µm) |
| Mouse 3 | 2 infiltrate foci (26–69 µm) |
| Mouse 4 | 1 infiltrate foci (32 µm) |
| Mouse 5 | 3 infiltrate foci (11–22 µm) |
| Mouse 6 | 0 infiltrate foci |