Figure 2.
Levels of luteinizing hormone (LH) secretion and AUC after treatment with VH (5 µL DMSO icv plus 200 µL saline iv), CC (10 µg compound C icv plus 200 µL saline iv), gonadotropin-releasing hormone (GnRH) (5 µL DMSO icv plus 32.5 nmol/kg iv) or CC + GnRH (10 µg compound C plus 32.5 nmol/kg iv). Administration of the peptides took place after stabilization of the animals following the third sampling point (indicated as time 0). Values are given as the mean ± SEM. p < 0.05; two-way ANOVA repeated measures followed, in case of hormone profile, by a post hoc Bonferroni’s test (groups with different superscript letters are statistically different).