TABLE 26.

Important drug–drug interactions between antimalarial agents and antiretroviral therapy drugs.

Drug	Antimalarial agent	Direction of interaction	Recommendation
InSTI	Coartem (artemether–lumefantrine)	No interaction	Safe to use
	Atovaquone–proguanil	No interaction	Safe to use
EFV	Coartem	↓ Artemether and lumefantrine concentrations	Use but might need to repeat the 3-day course of Coartem
	Atovaquone–proguanil	↓ Atovaquone and proguanil concentrations	Avoid co-administration
NVP	Coartem	No interaction	Use
	Atovaquone–proguanil	↓ Atovaquone concentrations	Avoid co-administration
PI/r	Coartem	↑ Lumefantrine concentrations	No dose adjustment necessary
	Atovaquone–proguanil	↓Atovaquone and proguanil concentrations	Avoid co-administration

ART, antiretroviral therapy; EFV, efavirenz; InSTI, integrase strand transfer inhibitor; NVP, nevirapine; PI/r, ritonavir-boosted protease inhibitor.