Table 1.
Patients’ clinical characteristics.
| MI + ALA + FA (n = 20) |
FA-Only (n = 20) |
p | |
|---|---|---|---|
| Age (years) | 35 ± 5.5 | 37.2 ± 3.3 | ns |
| BMI (kg/m2) | 29.9 ± 2 | 29.6 ± 2.3 | ns |
| AMH (ng/mL) | 2.9 ± 2.6 | 2.8 ± 2.6 | ns |
| AFC (n) | 15.9 ± 8.9 | 14.3 ± 7.4 | ns |
| Total exogenous FSH (IU) | 3090 ± 1000 | 3053 ± 890.3 | ns |
| OSI (n) | 2.8 ± 2 | 3.3 ± 2.3 | ns |
| Peak E2 (pg/mL) | 1735 ± 689 | 2286 ± 1147 | ns |
| Endometrial thickness (mm) | 11.4 ± 2.2 | 9.9 ± 1.8 | <0.05 |
| Retrieved oocytes (n) | 7.8 ± 4 | 8.5 ± 4.3 | ns |
| Mature (MII) oocytes (n) | 6.6 ± 3.3 | 7.3 ± 4 | ns |
| Maturation rate (%) | 84.3 ± 17.2 | 87.3 ± 16.2 | ns |
| Fertilized oocytes (n) | 4.3 ± 2.5 | 4.7 ± 3.1 | ns |
| Fertilization rate (%) | 69.9 ± 25 | 64.6 ± 20.1 | ns |
| Cleaved embryos (n) | 4.2 ± 2.4 | 4.6 ± 3.2 | ns |
| Cleavage rate (%) | 98.5 ± 4.8 | 97.4 ± 8.4 | ns |
| Mean embryo score | 7.4 ± 2.3 | 6.7 ± 2.1 | <0.01 |
| Top quality embryos (n) | 1.9 ± 1.5 | 1.2 ± 1.8 | ns |
| Top quality embryos (%) | 45.2 (38/84) | 26.1 (24/92) | <0.01 |
BMI = body mass index; AFC = antral follicle count; E2 = estradiol; OSI = ovarian sensitivity index (number of retrieved oocytes × 1000/total FSH dose). MI + ALA + FA group = patients assuming Myo-Inositol + Alpha-Lipoic acid + Folic acid; FA-only group = patients assuming Folic acid alone. Data are shown as mean ± SD or as absolute values and percentage; ns = not significant.