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BRCA1 functional domains and gene location of BRCA1 PVs in bilateral breast cancer patients. Abbreviations: BRCT, BRCA1 C-terminus domain; NLS, nuclear localization sequence; PVs, pathogenic variants; SCD, serine cluster domain. * This PV is present together with the BRCA2 PV named c.8331+2T>C in one patient showing double heterozygosity for BRCA1 and BRCA2 PVs.
