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. 2020 Sep 9;12(9):2564. doi: 10.3390/cancers12092564

Figure 7.

Figure 7

In vivo antitumor activity of BMNPs under the influence of an alternating magnetic field (AMF): (A) Images taken with a thermic camera of a representative mouse without (left) and with (right) injected BMNPs during AMF treatment. Note the different colors within the circle on the backside of the mouse. (B) Effect on the growth of 4T1 tumors (n = 8) in female BALB/c mice, analyzed 3 and 5 days after one single injection of DOXO-BMNPs or not functionalized BMNPs ± AMF: Each group received one intratumor injection of 3 mg BMNPs/mouse on the first day of the treatment (day 0). For the groups injected with soluble DOXO or DOXO-BMNPs, the dose of DOXO (either soluble or adsorbed on the BMNPs) was 80 µg/mouse. Differences between groups (all compared to PBS) were assessed by 2-way ANOVA with Dunnett’s multiple comparison test (*** p < 0.0001; ** p = 0.001). Weight (C) and necrosis % (D) of tumors were measured at the end of the experiment (day 5), and all samples were compared to the PBS group. Differences between groups were assessed by ordinary one-way ANOVA with Dunnett’s multiple comparison test (*** p < 0.05; * p = 0.001).