Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Distribution of genetic variants according to allelic frequency and effect size on the phenotype in quantitative traits. Individuals with extreme phenotypes will show a burden of rare variations with a moderate to large effect size (modified from Manolio et al., 2008 [19]).
