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. 2020 Aug 26;9(9):1966. doi: 10.3390/cells9091966

Table 5.

DEGs found both in the SN and putamen from PD patients and controls.

ENSEMBL Gene Symbol Protein Name Protein Function
Upregulated
ENSG00000089041 P2RX7 P2X purinoceptor 7 ATP receptor that acts as a ligand-gated ion channel
ENSG00000119699 TGFB3 Transforming growth factor beta-3 proprotein Embryogenesis and cell differentiation
ENSG00000120729 MYOT Myotilin Myofibril assembly and stability
ENSG00000125551 PLGLB2 Plasminogen-like protein B2 Unknown
ENSG00000127530 OR7C1 Olfactory receptor 7C1 Odorant receptor
ENSG00000159842 ABR Active breakpoint cluster region-related protein GTPase-activating protein for RAC and CDC42
ENSG00000168209 DDIT4 DNA damage-inducible transcript 4 protein Regulates cell growth, proliferation and survival in response to cellular energy levels and cellular stress
ENSG00000180015 NA
ENSG00000186352 ANKRD37 Ankyrin repeat domain-containing protein 37 Unknown
ENSG00000188269 OR7A5 Olfactory receptor 7A5 Odorant receptor
ENSG00000214313 AZGP1P1 Pseudogene
ENSG00000234769 NA
ENSG00000244921 NA
ENSG00000255823 MTRNR2L8 Humanin-like 8 Unknown
ENSG00000272755 NA
Downregulated
ENSG00000074317 SNCB Beta-synuclein Regulator of SNCA
ENSG00000078401 EDN1 Endothelin-1 Vasoconstrictor peptide
ENSG00000099957 P2RX6 P2X purinoceptor 6 ATP receptor that acts as a ligand-gated ion channel
ENSG00000103199 ZNF500 Zinc finger protein 500 Transcriptional regulation
ENSG00000137267 TUBB2A Tubulin beta-2A chain Major constituent of microtubules
ENSG00000148803 FUOM Fucose mutarotase Interconversion between alpha- and beta-L-fructose
ENSG00000155367 PPM1J Protein phosphatase 1J Serine/threonine protein phosphatase
ENSG00000164082 GRM2 Metabotropic glutamate receptor 2 Glutamate receptor
ENSG00000167306 MYO5B Unconventional myosin-Vb Vesicular trafficking
ENSG00000171532 NEUROD2 Neurogenic differentiation factor 2 Transcriptional regulation, implicated in neuronal determination
ENSG00000172794 RAB37 Ras-related protein Rab-37 GTPase that regulates vesicle trafficking
ENSG00000174807 CD248 Endosialin Angiogenesis
ENSG00000185567 AHNAK2 Protein AHNAK2 Calcium signaling
ENSG00000196972 SMIM10L2B Small integral membrane protein 10-like protein 2B Unknown
ENSG00000198563 DDX39B Spliceosome RNA helicase DDX39B mRNA export from the nucleus to the cytoplasm; spliceosome assembly
ENSG00000234944 LOC101929445 Non protein coding—LINC02623
ENSG00000272789 NA
ENSG00000277400 MAFIP MaFF-interacting protein Coactivator of MAFF transcriptional activity

Up- and down-regulated DEGs found both in the SN and putamen samples, in the same direction. The table includes the ENSEMBL identification, gene symbol (when available), protein name (UniProt) and short summary of the protein function. Protein functions that are not certain are in italics.