Table 5.
DEGs found both in the SN and putamen from PD patients and controls.
ENSEMBL | Gene Symbol | Protein Name | Protein Function |
---|---|---|---|
Upregulated | |||
ENSG00000089041 | P2RX7 | P2X purinoceptor 7 | ATP receptor that acts as a ligand-gated ion channel |
ENSG00000119699 | TGFB3 | Transforming growth factor beta-3 proprotein | Embryogenesis and cell differentiation |
ENSG00000120729 | MYOT | Myotilin | Myofibril assembly and stability |
ENSG00000125551 | PLGLB2 | Plasminogen-like protein B2 | Unknown |
ENSG00000127530 | OR7C1 | Olfactory receptor 7C1 | Odorant receptor |
ENSG00000159842 | ABR | Active breakpoint cluster region-related protein | GTPase-activating protein for RAC and CDC42 |
ENSG00000168209 | DDIT4 | DNA damage-inducible transcript 4 protein | Regulates cell growth, proliferation and survival in response to cellular energy levels and cellular stress |
ENSG00000180015 | NA | ||
ENSG00000186352 | ANKRD37 | Ankyrin repeat domain-containing protein 37 | Unknown |
ENSG00000188269 | OR7A5 | Olfactory receptor 7A5 | Odorant receptor |
ENSG00000214313 | AZGP1P1 | Pseudogene | |
ENSG00000234769 | NA | ||
ENSG00000244921 | NA | ||
ENSG00000255823 | MTRNR2L8 | Humanin-like 8 | Unknown |
ENSG00000272755 | NA | ||
Downregulated | |||
ENSG00000074317 | SNCB | Beta-synuclein | Regulator of SNCA |
ENSG00000078401 | EDN1 | Endothelin-1 | Vasoconstrictor peptide |
ENSG00000099957 | P2RX6 | P2X purinoceptor 6 | ATP receptor that acts as a ligand-gated ion channel |
ENSG00000103199 | ZNF500 | Zinc finger protein 500 | Transcriptional regulation |
ENSG00000137267 | TUBB2A | Tubulin beta-2A chain | Major constituent of microtubules |
ENSG00000148803 | FUOM | Fucose mutarotase | Interconversion between alpha- and beta-L-fructose |
ENSG00000155367 | PPM1J | Protein phosphatase 1J | Serine/threonine protein phosphatase |
ENSG00000164082 | GRM2 | Metabotropic glutamate receptor 2 | Glutamate receptor |
ENSG00000167306 | MYO5B | Unconventional myosin-Vb | Vesicular trafficking |
ENSG00000171532 | NEUROD2 | Neurogenic differentiation factor 2 | Transcriptional regulation, implicated in neuronal determination |
ENSG00000172794 | RAB37 | Ras-related protein Rab-37 | GTPase that regulates vesicle trafficking |
ENSG00000174807 | CD248 | Endosialin | Angiogenesis |
ENSG00000185567 | AHNAK2 | Protein AHNAK2 | Calcium signaling |
ENSG00000196972 | SMIM10L2B | Small integral membrane protein 10-like protein 2B | Unknown |
ENSG00000198563 | DDX39B | Spliceosome RNA helicase DDX39B | mRNA export from the nucleus to the cytoplasm; spliceosome assembly |
ENSG00000234944 | LOC101929445 | Non protein coding—LINC02623 | |
ENSG00000272789 | NA | ||
ENSG00000277400 | MAFIP | MaFF-interacting protein | Coactivator of MAFF transcriptional activity |
Up- and down-regulated DEGs found both in the SN and putamen samples, in the same direction. The table includes the ENSEMBL identification, gene symbol (when available), protein name (UniProt) and short summary of the protein function. Protein functions that are not certain are in italics.