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. 2020 Sep 2;9(9):2844. doi: 10.3390/jcm9092844

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Treatment of cell lines with H₂O₂ and measurement of γ-H2AX foci (A,C,E,G) and H2AX gene expression (B,D,F,H) in BRCA2 mutant PEO1 cell line (A,B), in comparison with BRCA2 silent mutant cell line PEO4 (C,D) and BRCA2 wild type SKOV3 (E,F) and MDAH-2774 (G,H). NS; No Supplement. Panel A. 1-hr: *** p < 0.0001, 24-hrs: *** p < 0.0001 (compared to NS). Panel B. 1-hr: ** p = 0.0056, 24-hrs: * p = 0.0322 (compared to NS). Panel C. 1-hr: *** p < 0.0001 (compared to NS). *** p < 0.0001 (1-hr compared to 24-hrs). Panel D. 1-hr: * p = 0.0375, 24-hrs: ** p = 0.0016 (compared to NS). ** p = 0.0078 (1-hr compared to 24-hrs). Panel E. 1-hr: *** p < 0.0001, 24-hrs: *** p < 0.0001 (compared to NS). *** p < 0.0001 (1-hr compared to 24-hrs). Panel F. 1-hr: * p = 0.0134, 24-hrs: *** p < 0.0001 (compared to NS). Panel G. 1-hr: *** p < 0.0001 (compared to NS). *** p < 0.0001 (1-hr compared to 24-hrs).