Table 3.
Predictors for declined eGFR and elevated UACR in T2D patients
| Parameter | Crude OR (95% CI), p-Value | Adjusted OR (95% CI), p-Value |
|---|---|---|
| eGFR <60 mL/min × 1.73 m2 1 | ||
| IL-17A, pg/mL | 1.04(1.01–1.09), p = 0.004 | 1.03(1.01–1.09), p = 0.01 |
| MIP-1α, pg/mL | 1.30(1.06–1.49), p = 0.02 | 1.15(1.02–1.50), p = 0.03 |
| Serum hs-CRP, mg/L | 1.01(0.96–1.05), p = 0.10 | 1.20(1.02–1.30), p = 0.02 |
| Age, years | 1.06 (0.98–1.15), p = 0.16 | 1.04(0.99–1.14), p = 0.08 |
| UACR ≥3.0 mg/mmol 2 | ||
| Eotaxin, 10 pg/mL | 0.98(0.94–1.00), p = 0.09 | 0.95(0.90–1.00), p = 0.03 |
| IL-15, 10 pg/mL | 1.03(0.98–1.06), p = 0.20 | 1.04(0.98–1.07), p = 0.09 |
The multiple logistic regression models of declined eGFR (1) and elevaled UACR (2); 1 The characteristics of the model 1: Intercept = −5.56, KS p-value < 0.0001, AUC = 0.78, Se = 0.72, Sp = 0.73, LP = 0.48, HL GOF p-value = 0.57; 2 The characteristics of the model 2: Intercept = 0.516, KS p-value = 0.02, AUC = 0.68, Se = 0.64, Sp = 0.62 for LP = 0.50, HL GOF p-value = 0.12.CKD−: The group of individuals with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and urinary albumin-to-creatinine ratio (UACR) <3.0 mg/mmol; NA-CKD: Non-albuminuric chronic kidney disease, the group of individuals with eGFR <60 mL/min/1.73 m2 and UACR <3.0 mg/mmol; A-CKD−: Group of patients with eGFR ≥60 mL/min/1.73 m2 and UACR ≥3.0 mg/mmol; A-CKD+: Group of individuals with eGFR <60 mL/min/1.73 m2 and UACR ≥3.0 mg/mmol.