Table A2.
Panel of cytokines and growth factors assessed in the study
| Family | Protein |
|---|---|
| Archetypical cytokines signaling through classical-cytokine receptors Type I helical Cytokine families signaling through Class I cytokine receptors (CRF1 family or Hematopoietin family) | |
| IL-2 Family, or Common Gamma Chain Receptor Family | IL-2, IL-4 subfamily(IL-4, IL-13), IL-9, IL-15, and IL-7 subfamily(IL-7) |
| Common Beta Chain Receptor Cytokine Family | IL-5, Colony Stimulating Factor 2/Granulocyte Monocyte-Stimulating Factor (CSF2/GM-CSF) |
| Prolactin family | Colony Stimulating Factor 3/Granulocyte-Stimulating Factor (CSF3/G-CSF) |
| IL-6 Family | IL-6 |
| IL-12 Family | IL-12 (p70) |
|
Type II Cytokine families signaling through Class II cytokine receptors
(CRF2 family or IL-10/IFN superfamily) | |
| IL-10 Family | IL-10 |
| Type II IFN | IFNγ |
|
Cytokine families signaling through immunoglobulin (Ig) superfamily cytokine receptors non-Receptor tyrosine-kinase (RTK) | |
| IL-1 Family | IL-1β, IL-1Ra |
| Cytokine TNF family signaling through TNF receptor family | |
| Family A | TNFα (TNFSF2) |
| Chemokine superfamily signaling through chemokine receptors (seven-transmembrane heptahelical(serpentine) receptors associated with G-protein trimeric system) | |
| Chemokine CC Motif Ligand Family (CCL) | MCP1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4), RANTES (CCL5) and eotaxin(CCL11) |
| Chemokine CXC Motif Ligand Family (CXCL) | IP-10 (CXCL10), IL-8 (CXCL8) |
| Orphan and other cytokine family members | |
| IL-17 Family | IL-17A |
| Growth factors and signaling proteins | |
| Platelet-Derived Growth Factor Family | PDGF-BB (Platelet-Derived Growth Factor subunit B) |
| Vascular Endothelial Growth Factor Family | VEGF (Vascular Endothelial Growth Factor)/Vascular Permeability Factor (VPF) |
| Fibroblast Growth Factor Family | bFGF(FGF2/FGF-β) |