Table 1.
List of identified proteins from the protein corona (PC) of CA-in-DMEM, CA-in-DMB and HA.
| Accession | Mass (Da) | pI | Identified Protein | Molecular Function | Biological Process | CA-in-DMEM | CA-in-DMB | HA |
|---|---|---|---|---|---|---|---|---|
| Q546G4 | 68693 | 5.75 | Albumin 1 | Albumin gene family | Carrier protein | ✓ | ✓ | ✓ |
| A0A0G2JGM6 | 14173 | 5.46 | Vitamin D-binding protein | · | ✓ | · | ||
| Q3TIU3 | 37298 | 5.94 | Alpha-2-HS-glycoprotein | Protease inhibitor | carrier protein, bone matrix metabolism, binds Ca and phosphate | ✓ | ✓ | ✓ |
| Q3UEK5 | 37280 | 6.04 | Alpha-2-HS-glycoprotein | ✓ | ✓ | ✓ | ||
| Q3UEK9 | 37326 | 6.04 | Alpha-2-HS-glycoprotein isoform CRA_a | ✓ | ✓ | ✓ | ||
| Q711L0 | 22677 | 8.9 | Secreted phosphoprotein 24 | Protease inhibitor | Bone remodelling | ✓ | ✓ | ∘ |
| D3YTY9 | 53205 | 4.95 | Kininogen-1 | Protease inhibitor | Blood coagulation | · | ✓ | ∘ |
| A0A0R4J0I1 | 46673 | 5.04 | MCG1051009/Serine protease inhibitor A3K | Alpha 1-antichymotrypsin | Acute phase | ∘ | ✓ | ∘ |
| A0A0R4J0X5 | 45854 | 5.32 | Alpha-1-antitrypsin 1-3 | Alpha 1-antitrypsin | ∘ | ✓ | ∘ | |
| A0A0A0MQA3 | 48796 | 5.98 | Alpha-1-antitrypsin 1-1 | ∘ | ✓ | ∘ | ||
| Q3KQQ4 | 45896 | 5.31 | Serpina1a protein | ∘ | ✓ | ∘ | ||
| A0A1B0GS57 | 21329 | 6.58 | Hemopexin | Heme/iron binding | Heme/iron binding and oxygen transport | ✓ | ✓ | · |
| Q8K1U6 | 31047 | 7.64 | Hemopexin | ✓ | ✓ | · | ||
| D3YYR8 | 25676 | 8.34 | Transferrin | · | ✓ | · | ||
| A0A0C6E3V3 | 51022 | 6.82 | HC protein/alpha-1-microglobulin | · | ✓ | · | ||
| Q9QWJ3 | 12907 | 6.78 | Alpha-1-globin | Hemoglobin alpha subunit | ✓ | ✓ | · | |
| Q91VB8 | 15112 | 7.97 | Alpha globin 1 | ✓ | ✓ | · | ||
| A8DUV3 | 15085 | 7.97 | Alpha-globin | ✓ | ✓ | · | ||
| D0U270 | 15840 | 7.13 | Beta-globin | Hemoglobin beta subunit | ✓ | ✓ | · | |
| A8DUP5 | 15894 | 7.09 | Beta-globin | ✓ | ✓ | · | ||
| A8DUK0 | 15840 | 7.13 | Beta-globin | ✓ | ✓ | · | ||
| A8DUP7 | 15826 | 7.13 | Beta-globin | ✓ | ✓ | · | ||
| Q61650 | 5690 | 4.65 | Beta-globin | ✓ | ✓ | · | ||
| A8DUM2 | 15780 | 7.13 | Beta-globin | ✓ | ✓ | · | ||
| D4N6U4 | 15880 | 7.13 | Beta-globin | ✓ | · | · | ||
| B1Q450 | 15840 | 7.13 | Beta-globin | ✓ | · | · | ||
| D0U269 | 15854 | 7.13 | Beta-globin | ✓ | · | · | ||
| Q9CY06 | 15112 | 7.97 | Globin domain-containing protein | Heme, iron, binding | ✓ | ✓ | · | |
| Q9CY10 | 15202 | 8.95 | Globin domain-containing protein | ✓ | ✓ | · | ||
| Q8BPF4 | 15181 | 8.72 | Globin domain-containing protein | ✓ | ✓ | · | ||
| Q6LD55 | 11319 | 6.57 | APOAII | Lipid binding and transport | Opsonin | · | ✓ | · |
| A7YL62 | 11291 | 6.57 | Apolipoprotein A-II | · | ✓ | · | ||
| H7BX99 | 70212 | 6.04 | Prothrombin | Clotting factor | Blood coagulation | · | ✓ | · |
| Q3TJ94 | 70269 | 6.04 | Prothrombin | · | ✓ | · | ||
| A0A075B5P6 | 50063 | 6.6 | Ig mu chain C region | Immunoglobulin | Complement activator, Opsonin | · | ✓ | · |
| A0A075B6A0 | 52618 | 5.99 | Ig mu chain C region | · | ✓ | · | ||
| A0A075B5P4 | 35752 | 7.2 | Ig gamma-1 chain C region | · | ✓ | · | ||
| A0A0A6YWR2 | 43434 | 6.02 | Ig gamma-1 chain C region | · | ✓ | · | ||
| Q99LC4 | 51008 | 6.6 | Igh protein | · | ✓ | · | ||
| I6L985 | 51976 | 8.12 | Igh protein | · | ✓ | · | ||
| E9Q9C6 | 275239 | 4.86 | Fc fragment of IgG-binding protein | Immunoglobulin binding protein | · | · | ✓ | |
| E9Q0B5 | 275224 | 4.87 | Fc fragment of IgG-binding protein | · | · | ✓ | ||
| A2A513 | 57041 | 5 | Keratin type I cytoskeletal 10 | Epithelial intermediate filament | mechanical support | ✓ | ✓ | ✓ |
| Q9CV72 | 30011 | 5.4 | IF rod domain-containing protein | · | · | ✓ | ||
| Q3UV11 | 59526 | 8.32 | Keratin type II cytoskeletal 6B | · | · | ✓ | ||
| Q0VDR7 | 60273 | 8.33 | Krt6b protein | · | · | ✓ | ||
| Q32P04 | 61767 | 7.59 | Keratin 5 | · | · | ✓ | ||
| Q08EK4 | 61302 | 7.73 | Keratin 77 | · | · | ✓ | ||
| B1AQ78 | 44542 | 5.28 | Keratin 19 | · | · | ✓ | ||
| B1AQ77 | 49494 | 4.79 | Keratin 15 isoform CRA_a | · | · | ✓ | ||
| B2RTP7 | 70923 | 8.26 | Krt2 protein | · | · | ✓ |