Table 2.
Ongoing clinical trials with BCMA antibody-drug conjugate.
| DRUG NAME | TRIAL NAME | NCT Number | PHASE | Setting | Combination with Other Drugs | Comparator Arm |
|---|---|---|---|---|---|---|
| GSK2857916 | BMA117159 | NCT02064387 | I | RRMM | / | / |
| DREAMM-2 | NCT03525678 | II | RRMM | / | / | |
| DREAMM-3 | NCT04162210 | III | RRMM | / | Pomalidomide/Dexamethasone | |
| DREAMM-4 | NCT03848845 | I/II | RRMM | Pembrolizumab | / | |
| DREAMM-5 | NCT04126200 | I/II | RRMM | GSK3174998 GSK3359609 Nirogacestat |
/ | |
| DREAMM-6 | NCT03544281 | I/II | RRMM | Lenalidomide/Dexamethasone Bortezomib/Dexamethasone |
/ | |
| DREAMM-7 | NCT04246047 | III | RRMM | Bortezomib/Dexamethasone | Daratumumab/Bortezomib/Dexamethasone | |
| DREAMM-8 | NCT04484623 | III | RRMM | Pomalidomide/Dexamethasone | Pomalidomide/Bortezomib/dexamethasone | |
| MCRN 007 | NCT03715478 | I/II | RRMM | Pomalidomide/Dexamethasone | / | |
| 209664 | NCT04091126 | I | NDMM | Bortezomib/Lenalidomide/Dexamethasone | / | |
| MEDI2228 | D7900C00001 | NCT03489525 | I | RRMM | / | / |
| CC99712 | CC-99712-MM-001 | NCT04036461 | I | RRMM | / | / |
Abbreviations: RRMM, relapsed/refractory multiple myeloma; NDMM, newly diagnosed multiple myeloma