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. 2020 Aug 21;9(9):1941. doi: 10.3390/cells9091941

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relationship between TSPO density and amyloid load in the hippocampus of 3xTg-AD mice and TgF344-AD rats. TSPO density and amyloid load were determined by in situ autoradiography with [¹²⁵I]CLINDE and [¹²⁵I]DRM106 in 3xTg-AD mice (A,B) and TgF344-AD rats (C,D). A positive correlation was observed in the dorsal hippocampus (A,C) but not in the ventral hippocampus (B,D). r = Spearman’s correlation coefficient. Mouse data were published in Reference [101], and rat data are personal observations.