Skip to main content
. 2020 Sep 2;10(9):1264. doi: 10.3390/biom10091264

Figure 4.

Figure 4

Co-application of zinc at a concentration of 30 µM leftward shifted pH dose–response curve of heteromeric ASIC1a/3 currents. (A) Representative traces show that co-application of zinc at a concentration of 30 µM potentiated heteromeric ASIC1a/3 currents with pH dependence; (B) Co-application of zinc at a concentration of 30 µM shows a leftward shift of the pH50 from 6.54 ± 0.05 without co-application of zinc to 6.77 ± 0.05 with co-application of zinc at a concentration of 30 µM (p < 0.05, n = 5). Whole-cell patch-clamp recording was performed. Relative peak amplitude with or without zinc treatment was measured by ASIC current (I) on a drop in pH from 7.4 to 7.0, 6.8, 6.5, 6.0, 5.0, or 4.0 divided by ASIC current (IpH5.0) on a drop in pH from 7.4 to 5.0. Data are presented as mean ± SEM. CTRL, control. * p < 0.05.