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. 2020 Jul 20;8(3):396. doi: 10.3390/vaccines8030396

Figure 4.

Figure 4

Rash burden. Group median peak (Day 16) lesion counts are shown for all animals that received 170× LD50 MPXV dose (A) and 2× LD50 (B) for both Day 1 (left symbol) and Day 3 (right symbol) for all groups—unvaccinated (gray circles), Dryvax®-vaccinated (white square – 170× LD50 study only) ACAM2000®-vaccinated (black squares) and IMVAMUNE®-vaccinated animals (black triangles). No significant differences were seen between vaccine group or vaccination timing by two-way ANOVA (p < 0.05). Group median secondary lesion counts at each time-point are shown for animals challenged with 2× LD50 dose of monkeypox virus and either unvaccinated (gray circles) or vaccinated 1 day postexposure (C) or 3 days postexposure (D) with ACAM2000® (black squares) or IMVAMUNE® (black triangles). Euthanized animals for each vaccine group are indicated on the day of euthanasia (same symbols as above). Only animals vaccinated with IMVAMUNE® on Day 1 postexposure differed significantly from unvaccinated controls by two-way ANOVA (p < 0.05).