Figure 8.
Jennerian pustule “takes”. Kaplan–Meier survival curves for animals from previous and current studies challenged with 2× LD50 dose of monkeypox virus and vaccinated with ACAM2000® or Dryvax® either 30 days prior to challenge or 1 or 3 days postexposure (A) and which manifested a take at the vaccine site (black squares) or did not (gray circles). Survival was significantly higher for animals who manifested a take by log-rank (Mantel–Cox) test (* p > 0.05). Comparison of multiple studies with animals challenged with 2× LD50 dose of monkeypox virus and vaccinated with ACAM2000® or Dryvax® at Day −30 pre-exposure, 1 day postexposure, or 3 days postexposure (B), showing percentage of animals that manifested a take (brown) or did not manifest a take (black).