Figure 3.

Remdesivir bound to the primer RNA inside the central channel of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12 (pdb id 7bv2 described in [12]). (a) Three RNA polymerase chains, NSP 12, NSP7, and NSP8, are represented as blue, cyan, and dark cyan ribbons. Remdesivir is represented as green atoms and pyrophosphate as dark green atoms. The dashed lines represent protein segments missing from the deposited structure. (b) The same structure rotated approximately 180° around the vertical axis. (c) Remdesivir and pyrophosphate inside the binding pocket, surrounded by the yellow SAGNM predictions (left), and inside the pocket with contact residues colored by hydrophobicity.