Fig. 3.

Proposed model of increased risk for type 2 diabetes in individuals with a 22q11.2 microdeletion.

Diagram illustrating the proposed relationships between the 22q11.2 deletion and risk of type 2 diabetes, including clinical variables with known enrichment in individuals with 22q11.2DS. The direction of proposed relationships is indicated by arrows. Orange arrows (solid, significant findings) indicate evidence derived from the current study. Green dashed arrows indicate relationships suggested by previous studies of 22q11.2DS; blue dashed arrows indicate evidence from previous studies of T2D risk factors in the general population [5,6,11,21]. The green and blue dashed lines unaccompanied by orange lines indicate possible mediation effects that the current study did not investigate. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)