Table 2.

Multivariate analysis of the 22q11.2 microdeletion and other variables on type 2 diabetes risk in Canadian adults aged 17–69 years^a.

Variablesb	Type 2 diabetes (T2D)				Multivariate logistic regression analysisc
	No (n = 11,506)		Yes (n = 682)
	na		na		OR	95% CI
Non-European ethnicity	2368		182		3·48	2·83–4·28
Family history of T2D	2150		298		2·57	2·16–3·06
22q11.2 microdeletiond	289		25		2·44	1·39–4·31
Antipsychotic use	231		32		1·78	1·09–2·92
Male sex	5671		362		1·51	1·28–1·80
	Mean	SD	Mean	SD
Age (years)	41·2	14·4	55·8	9·4	2·59	2·39–2·82
Body mass index	26·8	5·5	32·0	7·2	1·90	1·77–2·03

OR = Odds ratio; CI = Confidence interval; SD = Standard deviation.

^aSurvey weights used to obtain population estimates for analyses were based on originating samples involving n = 12,188 participants (n = 11,874 from a Canadian population sample; n = 314 with 22q11.2 deletion syndrome); see Methods for details.

^bDefinitions for variables are outlined in Methods. Continuous variables, age and body mass index (BMI; used as a proxy for obesity), were analysed using increments of 10 and 5, respectively.

^cLikelihood ratio for model: χ² = 1317·65, df = 7, p <0·0001; significant results are in bold font.

^dAscertained through specialty clinic for adults with 22q11.2 deletion syndrome (n = 314); data on 22q11.2 deletion status for the population-based sample (estimated n = 0–3) unavailable; see Methods for details.