Figure 1.

The phylogenetic tree of Drosophila melanogaster TRP channels and mouse TRPC channels. The multiple sequence alignment was performed using the MUSCLE algorithm. The length of branches is shown under the lines, indicating the number of substitutions per site. The scale bar is also included under the plot for convenience. Based on the phylogenic tree, mouse TRPCs can be subdivided into four groups: TRPC1, TRPC2, TRPC4/5 and TRPC3/6/7. MegAlign Pro 17 of Lasergene 17 software was used to align and construct the tree. The TRP protein accession numbers are shown on the right from the name of each protein.