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. 2020 Sep 5;8(9):1360. doi: 10.3390/microorganisms8091360

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Specific glucose-related microbial markers identified in T2D and RT2D patients (A) Microbial markers from LEfSe and heatmap analysis were reconfirmed by Ribosomal Database Project (RDP) classification. As shown, the relative proportions of A. muciniphila and Fusobacterium were reduced and those of B. vulgatus and V. denticariosi were significantly increased in fecal samples from RT2D patients. (B) The average value from the percentages of Bacteroides vulgatus minus the sum of the percentages of A. muciniphila, Fusobacterium and Veillonella denticariosi were used to distinguish RT2D patients from T2D patients (area under the curve (AUC) = 0.719). (C) The relative proportion of A. muciniphila was significantly negatively correlated with HbA1c. A p value less than ★ p < 0.05 and ★★ p < 0.01 indicates statistical significance.