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Simplified schematic representations of the three types of phage-based antigen delivery systems currently reported. An antigen delivery system based on a hybrid phage-DNA vaccine combines the concepts of the other two systems. It is based on a phage displaying on its surface peptides with specific affinity towards antigen presenting cells (APCs) and at the same time, it harbors a DNA plasmid encoding the therapeutic antigen in a eukaryotic expression cassette.
