Figure 5.

Systems biology analysis. (A) Biologically statistically significant protein interaction map showing enrichment of biological functions and pathways in PLum-AI cells that are central to cell migration, cell cycle regulation, cell damage, cell survival, DNA damage, and cell adhesion (Supporting Information Table S2). (B) Targeted analysis of prostate cancer interactome in PLum-AI cells vs. PLum-AD cells revealed dysregulation of proteins involved in cell differentiation, cell proliferation, cell cycle, and apoptosis (Supporting Information Table S3). Relationships among the differentially expressed proteins in PLum-AI cells vs. PLum-AD cells were determined using Elsevier’s Pathway Studio version 10.0 (Ariadne Genomics, Elsevier) and the Ariadne ResNet database [35,36].