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Open reading frame positions of ClinVar and COSMIC mutations. (A) Counts of unique residue mutation positions by mutation type. (B) Distribution histograms showing Kolmogorov–Smirnov P-values for uniformity. For COSMIC, only the 548 unique residues were mapped. (C) Histogram showing all COSMIC missense, nonsense, frameshift, and indel mutations (including duplicate) to identify hotspots. The mutations generating the three hotspots are shown.
