Table 1.
Coordinates and functions of MEN1 domains and interacting proteins.
| Gene or Region | MEN1 Coordinates (Amino Acids) | Function |
|---|---|---|
| MEN1 Domains | ||
| NTD | 1–100 | Crystal structure identified domain |
| Thumb | 101–1230 | Crystal structure identified domain |
| Palm | 231–1300 | Crystal structure identified domain |
| Fingers | 301–1305 | Crystal structure identified domain |
| NLS1 | 479–1497 | Nuclear localization sequence |
| NLS2 | 588–1608 | Nuclear localization sequence |
| NLS3 | 546–1672 | Nuclear localization sequence |
| NES1 | 33–151 | Nuclear exit sequence |
| NES2 | 253–1267 | Nuclear exit sequence |
| MEN1 Interacting Proteins | ||
| KMTA2 (MLL1) | ~230–1300 | Mixed lineage leukemia |
| LEDGF | ~1–1100 | Chromatin associated factor, required for MLL oncogenic transformation |
| JunD | 1–140, 323–1448 | Transcriptional activator, subunit of AP-1 transcription complex |
| HLXB9 | 41–1177, 323? | Homeobox gene involved in pancreas development, neural motor protein |
| SMAD3 | 41–1278, 477–1615 | TGFB signaling pathway, cell proliferation, transcriptional regulation |
| MYC | 360-615 (fingers), maybe NTD | Transcriptional regulation, cell cycle, apoptosis, cellular transformation |
| PEM (mouse) | 278–1476 | Homeobox gene, embryonic and placenta expression |
| NF-kB subunits | 305–1476 | Transcriptional regulators, inflammation, immune response, cell proliferation |
| SIRT1 | 305–1476 | Sirtuitin, gene silencing |
| SIN3A | 295–1450 | Gene expression regulator, embryogenesis, cell proliferation, senescence |
| HDAC1 | 295–1450 | Histone deacetylase, transcriptional regulator, cell proliferation and differentiation |
| PRMT5 | L22, A242 | Arginine methyltransferase, transcriptional regulation, DNA damage repair |
| FANCD2 | 219–1395 | Fancomi anemia complex subunit, DNA damage repair |
| RPA2 | 1–140, 286–1448 | Replication Protein A subunit |