Table 2.
Blood Examination and Cognitive Assessment Results in Breast Cancer Group at Three Time Points
| Median ± (IQRs) | P value | F value | P value | |||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | t0 | t1 | t2 | t0 vs t1 | t0 vs t2 | t1 vs t2 | ||
| E2 (pmol/L) | 265.0 (112.3–391.8) | 81.0 (52.0–125.0) | 138.0 (84.5–195.0) | 0.041 | 0.188 | 0.506 | 5.089 | 0.012c |
| FSH (IU/L) | 6.9 (3.9–40.1) | 70.1 (10.3–89.9) | 64.6 (19.9–112.2) | 0.031 | 0.385 | 0.965 | 2.958 | 0.075c |
| LH (IU/L) | 7.3 (2.2–25.4) | 34.5 (5.8–51.5) | 7.6 (3.4–29.0) | 0.662 | 0.926 | 0.156 | 3.344 | 0.106c |
| Hemoglobin (g/L) | 124.0 (110.0–134.0) | 121.0 (113.3–126.0) | 133.0 (123.5–142.0) | 0.989 | 0.325 | 0.003 | 3.876 | 0.075c |
| Fasting glucose (mmol/L) | 5.2 (4.7–7.2) | 5.4 (4.8–5.7) | 5.4 (5.2–5.7) | 0.677 | 0.523 | 0.832 | 0.215 | 0.808a |
| Total cholesterol (mmol/L) | 4.9 (4.3–5.7) | 5.0 (4.5–5.4) | 4.9 (4.7–5.2) | 0.745 | 0.732 | 0.990 | 0.076 | 0.927c |
| Triglycerides (mmol/L) | 1.49 (0.9–3.0) | 2.0 (1.44–3.70) | 2.1 (1.90–2.70) | 0.041 | 1.000 | 0.194 | 3.281 | 0.052a |
| SAS (score) | 29.0 (27.0–31.8) | 32 (32.0–35.0) | 27.0 (23.3–34.8) | 0.186 | 0.659 | 0.098 | 1.548 | 0.228a |
| SDS (score) | 27.5 (24.5–32.0) | 34.0 (33.0–34.0) | 29.0 (24.0–41.5) | 0.133 | 0.221 | 0.677 | 1.418 | 0.257c |
| Stroop-C (sec) | 15.3 (13.5–18.4) | 14.4 (12.9–15.5) | 14.4 (12.9–15.5) | 0.480 | 0.493 | 0.985 | 0.340 | 0.714c |
| Stroop-W (sec) | 22.0 (18.5–26.1) | 18.9 (17.1–20.1) | 19.0 (14.4–19.6) | 0.235 | 0.179 | 0.876 | 1.156 | 0.327c |
| Stroop-I (sec) | 31.5 (24.9–33.0) | 29.0 (25.0–34.7) | 24.0 (20.0–42.0) | 0.999 | 0.992 | 0.991 | 0.001 | 0.999c |
| NST (sec) | 47.2 (39.8–62.0) | 41.0 (39.5–51.5) | 53.0 (40.0–71.0) | 0.973 | 0.187 | 0.224 | 1.101 | 0.345c |
| DST (score) | 49.5 (34.0–61.8) | 54.0 (45.0–64.0) | 59.0 (43.0–60.0) | 0.798 | 0.855 | 0.672 | 0.093 | 0.912c |
| LTT (sec) | 59.8 (46.1–83.2) | 40.0 (28.2–48.5) | 39.0 (30.8–56.0) | 0.010 | 0.012 | 0.978 | 5.013 | 0.013c |
| MMSE (score) | 28.0 (27.0–29.5) | 29.0 (28.0–29.5) | 27.5 (26.3–29.8) | 0.431 | 0.301 | 0.879 | 0.619 | 0.545c |
| SDT (sec) | 37.4 (33.3–42.3) | 33.5 (30.9–38.7) | 32.0 (27.8–36.9) | 0.451 | 0.247 | 0.659 | 0.728 | 0.491c |
| WDT (score) | 24.0 (22.0–27.0) | 21.0 (17.5–27.5) | 18.0 (11.5–22.5) | 0.278 | 0.002 | 0.082 | 5.595 | 0.008c |
a: k-independent samples nonparametric tests; c: two-sample t test
Abbreviations: t0 baseline assessment, t1 one week after chemotherapy, t2 six months after chemotherapy, SD standard deviation, E2 estradiol, FSH follicle stimulating hormone, LH luteinizing hormone, DST digit symbol test, MMSE Mini-mental state examination, LTT line tracing test, NCT number connection test, SDT Serial dotting test, SDS Self-Rating Depression Scale, SAS Self-Rating Anxiety Scale, Stroop-C Stroop colour test, Stroop-W Stroop word test, Stroop-I Stroop interference test, WDT Auditory verbal learning memory