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. 2020 Sep 21;12(9):2709. doi: 10.3390/cancers12092709

Figure 5.

Figure 5

FOL-MSN-BTZ selectively affects mitochondrial function in MM cells. FR+ RPMI-8226 (RPMI) and FR- BJhTERT cells were treated or not (Control) with MSN-FOL, FOL-MSN-BTZ and free BTZ for 1 h and processed, after 24 h, for mitochondrial function analysis. Mitochondrial membrane potential and mitochondrial mass were assessed using MitoTracker Orange CM-H2TMRos and MitoTracker Deep Red probes, respectively, in RPMI and BJhTERT cells. The ratio between mitochondrial membrane potential and mitochondrial mass is also displayed. Values are expressed as mean ± SD of three independent experiments. (*) p < 0.05; (**) p < 0.01; (***) p < 0.001; (****) p < 0.0001.