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. 2020 Sep 17;10(9):645. doi: 10.3390/brainsci10090645

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The first Partial Least Squares (PLS) path model constructed in this study.PON1 Q192R: paraoxonase 1 (PON1) genotypes combined with PON1 4(chloromethyl)phenyl acetate (CMPA)ase activity.MDA: malondialdehyde; Pi: phosphatidylinositol; AOPs: adverse outcome pathways; MITOTOX: index of multiple immune and oxidative toxicity; TNF: tumor necrosis factor; Paracell: index of paracellular route breakdown; TRYCATs: IgA to tryptophan catabolites; SANS: the Scale for the Assessment of Negative Symptoms; PANSSneg: the negative subscale of the Positive and Negative Syndrome Scale; FTD: formal thought disorders; PMR: psychomotor retardation. HRQoL: health-related quality of life; WHO 1-4: World Health Organization Quality of Life Instrument domains (domains 1-4). The white figures in blue circles indicate the explained variance.