Table 1.
Cell activation sequence in the tumor cells (fold change 2 in log2 scale). For each mRNA sample, we used 4 biological replicates.
| Cell Activation Sequence | R | N | Genes |
|---|---|---|---|
| Endothelial→Ito→Kupffer | ↑ | 34 | 3110047P20Rik, AW060742, A_55_P1964173, A_55_P2091525, Abca17, Armcx3, Atp8a1, B930078G14Rik, Cd300a, Elavl4, Fam160a2, Fdxacb1, Fnbp1, Gm10914, Golga7b, Med13, Nhlh1, Npcd, Rdh1, Slc1a4, TC1648127, Zfp133-ps, chr10:69842010-69842465_F, chr11:53574182-53574644_R, chr14:78214602-78225827_F, chr17:17462450-17488725_R, chr1:138442536-138521080_F, chr1:182686731-182709331_F, chr4:131905739-131910814_R, chr5:74340084-74346709_R, chr6:136440100-136450050_F, chr6:146493273-146493932_R, chr8:35143801-35144482_F, chrX:120300373-120302404_F |
| ↓ | 0 | ||
| Endothelial→Kupffer→Ito | ↑ | 16 | 1300017J02Rik, Aadac, Afm, Ahsg, Apof, C8a, C8b, Cyp2a12, Cyp2d10, Cyp2d26, Habp2, Itih, Itih2, Serpinc1, Serpind1, Ugt2b36 |
| ↓ | 11 | Apln, Edn1 (10 probes) | |
| Ito→Endothelial→Kupffer | ↑ | 0 | |
| ↓ | 1 | Tm4sf4 |
R is the type of regulation across the cell sequence: ↑ up-regulation, ↓ down-regulation. N is the number of transcripts continuously up- or down-regulated across the cell sequence.